Who we are

Dr. Angela Mastaloudis, PhD is a nutrition biochemist and exercise physiologist specializing in metabolic and cognitive resilience providing science-based Personalized Nutrition and Wellness Consulting.

With more than 20 years of experience conducting nutrition research for the dietary supplement industry, she helps women navigate perimenopause and menopause with clarity and confidence. Her work centers on preserving muscle, supporting metabolic flexibility, improving recovery and maintaining mental sharpness through evidence-based nutrition, targeted supplementation and resistance training.

She works with everyday women who are ready to build resilience, improve flexibility, and feel stronger in daily life as well as former athletes who want to maintain (or regain) their physical capacity with confidence.

This is not about extreme training or restrictive diets.

It’s about Living Like a Betty!

Strengthen muscle. Support metabolism. Protect cognition. Enjoy the process.

Publications

  • Ph.D. Nutrition Biochemistry Oregon State University, Corvallis, OR   

    Dissertation Title: Inhibition of Exercise-Induced Oxidative Stress, Inflammation and Muscle Damage by Prior Supplementation with the Antioxidant Vitamins E and C

    M.S. Exercise Physiology Oregon State University, Corvallis, OR                                             

    Dissertation Title: Assessment of Oxidative Stress in Athletes During Extreme Exercise Using Deuterium-Labeled Vitamin E

    B.A.  Biological Sciences University of California at Santa Barbara, Santa Barbara, CA                   

    1. Mastaloudis, A.; Holcomb, L.; Fahey, J.; Olson, C.; Nieman, D.; Colin, Kay, C.; O'Donnell, R.; Pecorelli, A.; Kinney, M.; Li, Y.; Ishaq, S. and Valacchi, G. Active Exogenous Myrosinase from Mustard Seed Increases Bioavailability of Sulforaphane from a Glucoraphanin-Rich Broccoli Seed Extract in a Human Clinical Study. Communications Medicine-Nature. 2026 (Accepted pending revisions).

    2. Zhu, Z.; Cremonini, E.; Mastaloudis, A.; Mitchell, A.E.; Bornhorst, G.M. and Oteiza, P.I. Optimization of sulforaphane bioavailability from a glucoraphanin-rich broccoli seed extract in a model of dynamic gastric digestion and absorption by Caco-2 cell monolayers. Food and Function. 16(1):314–328; 2025. DOI: 10.1039/d4fo04561k

    3. Zhu, Z.; Cremonini, E.; Mastaloudis, A. and Oteiza, P.I. Glucoraphanin and sulforaphane mitigate TNFα-induced Caco-2 monolayers permeabilization and inflammation. Redox Biology. 76:103359; 2024. https://doi.org/10.1016/j.redox.2024.103359.

    4. Zhu, Z.; Lerno, L.; Cremonini, E.; Oteiza, P.I.; Mastaloudis, A.; Bornhorst, G.M. and Mitchell, A.E. Robust UHPLC-(ESI+)-MS/MS method for simultaneous analysis of glucoraphanin, sulforaphane, and sulforaphane metabolites in biological samples. ACS Food Science & Technology. 3(7):1300-1310; 2023. DOI: 10.1021/acsfoodscitech.3c00173

    5. Cremonini, E.; Daveri, E.; Iglesias, D.E.; Kang, J.; Wang, Z.; Gray, R.; Mastaloudis, A.; Kay, C.D.; Hester, S.N.; Wood, S.M.; Fraga, C.G.; Oteiza, P.I. A randomized placebo-controlled cross-over study on the effects of anthocyanins on inflammatory and metabolic responses to a high-fat meal in healthy subjects. Redox Biology. May;51:102273; 2022. DOI: 10.1016/j.redox.2022.102273. Epub 2022 Mar 1. PMID: 35255426

    6. De La Rosa, A.; Olaso-Gonzalez, G.; Garcia-Dominguez, E.; Mastaloudis, A.; Hester, S.N.; Wood, S.M.; Gomez-Cabrera, M.C.; Viña, J. Glucosamine Supplementation Improves Physical Performance in Trained Mice. Medicine & Science in Sports & Exercise. Mar 1;54(3):466-474; 2022. DOI: 10.1249/MSS.0000000000002821. PMID: 34711707.

    7. Cremonini, E.; Daveri, E.; Mastaloudis, A. and Oteiza, P.I. (–)-Epicatechin and anthocyanins modulate GLP-1 metabolism: evidence from mice and GLUTag L cells. Journal of Nutrition. Jun 1;151(6):1497-1506.; 2021. DOI: 10.1093/jn/nxab029. PMID: 33693759

    8. Gambini, J.; Gimeno-Mallench, L.; Olaso-Gonzalez, G.; Mastaloudis, A.; Traber, M.G.; Monleón, D.; Borrás, C. and Viña J. Moderate Red Wine Consumption Increases the Expression of Longevity-Associated Genes in Controlled Human Populations and Extends Lifespan in Drosophila melanogaster. Antioxidants (Basel). Feb 16;10(2):301; 2021. DOI: 10.3390/antiox10020301. PMID: 33669360.

    9. Mastaloudis, A.; Subramaniam, P.; Wood, S.M.; Hester, S.N.; McGlade, E.C.; Renshaw, P.F. and Yurgelun-Todd, D.A. Supplementation with a putative calorie restriction mimetic micronutrient blend increases glutathione concentrations and improves neuroenergetics in brain of healthy middle-aged men and women. Free Radical Biology and Medicine. Jun;153:112-121; 2020. DOI: 10.1016/j.freeradbiomed.2020.04.017. PMID: 32335159.

    10. Woodby, B.; Schiavone, M.L.; Pambianchi, E.; Mastaloudis, A.; Hester, S.N.; Wood, S.M.; Pecorelli, A. and Valacchi, G. Particulate Matter Decreases Intestinal Barrier-Associated Protein Levels in 3D Human Intestinal Model. International Journal of Environmental Research and Public Health. May;17(9):3234; 2020. DOI: 10.3390/ijerph17093234. PMID: 32384765. 

    11. Serna, E.; Mastaloudis, A.; Wood, S.M.; Hester, S.N.; Prolla T.A. and Vina, J. A novel micronutrient blend mimics calorie restriction transcriptomics in multiple tissues of mice and increases life and healthspan in C. elegans. Nutrients. Feb;12(2):486; 2020. DOI: 10.3390/nu12020486. PMID: 32075050.

    12. Cremonini, E.; Daveri, E.; Mastaloudis, A.; Adamo, A.M.; Mills, D.; Kalanetra, K.; Hester, S.N.; Wood, S.M.; Fraga, C.G. and Oteiza, P.I. Anthocyanins protect the gastrointestinal tract from high fat diet-induced alterations in redox signaling, barrier integrity and dysbiosis. Redox Biology. Sep;26:101269; 2019. DOI: 10.1016/j.redox.2019.101269. PMID: 31330482.

    13. Hester, S.N.; Mastaloudis, A.; Gray, R.; Antony, J.; Evans, M. and Wood, S.M. Efficacy of an anthocyanin and prebiotic blend on intestinal environment in obese male and female subjects. Journal of Nutrition and Metabolism. 7497260; 2018. DOI: 10.1155/2018/7497260. PMID: 30302287

    14. Daveri, E.; Cremonini, E.; Mastaloudis, A.; Hester, S.N.; Wood, S.M.; Waterhouse, A.L.; Anderson, M.; Fraga, C.G. and Oteiza, P.I. Cyanidin and delphinidin modulate inflammation and altered redox signaling improving insulin resistance in high fat-fed mice. Redox Biology. 18:16-24; 2018. DOI: 10.1016/j.redox.2018.05.012. PMID: 29890336.

    15. Cremonini, E.; Mastaloudis, A.; Hester, S.N.; Verstraeten, S.; Anderson, M.; Wood, S.M.; Waterhouse, A.L.; Fraga, C.G. and Oteiza, P.I. Anthocyanins inhibit tumor necrosis alpha-induced loss of Caco-2 cell barrier integrity. Food and Function. 8(8):2915-2923; 2017. DOI: 10.1039/c7fo00625j. PMID: 28740990.

    16. Barger, J.L.; Vann, J.M.; Cray, N.L.; Pugh, T.D.; Mastaloudis, A.; Hester, S.N.; Wood, S.M.; Newton, M.A.; Weindruch, R. and Prolla, T.A. Identification of tissue-specific transcriptional markers of caloric restriction in the mouse and their use to evaluate caloric restriction mimetics. Aging Cell. 16(4):750-760; 2017. DOI: 10.1111/acel.12608. PMID: 28556428.

    17. Wood, S.M.; Mastaloudis, A.F.; Hester, S.N.; Gray, R.; Kern, D.; Namkoong, J. and Draelos, Z.D. Protective effects of a novel nutritional and phytonutrient blend on ultraviolet radiation-induced skin damage and inflammatory response through aging defense mechanisms. Journal of Cosmetic Dermatology. 16(4):491-499; 2017. DOI: 10.1111/jocd.12295. PMID: 27885783.

    18. Barger, J.L.; Van, J.M.; Mastaloudis, A.; Wood, S.M.; Bartlett, M.R.; Prolla, T.A.; Weindruch, R. Identification of transcriptional targets of healthspan in adipose tissue and modulation by resveratrol. Nutrition and Aging. 2:157-63; 2014.

    19. Mastaloudis, A. and Wood, S.M. Age-related changes in cellular protection, purification and inflammation-related gene expression: role of dietary phytochemicals. Annals of the New York Academy of Sciences. 1259(1):112-120; 2012. DOI: 10.1111/j.1749-6632.2012.06610.x. PMID: 22758643

    20. Mastaloudis, A. A unique nutritional formulation to promote cellular protection and purification via induction of the Nrf2-mediated ARE/Phase II detoxification pathways. Second International Conference on Environmental Stressors in Biology and Medicine. Medimond s.l.r. Bologna, Italy. 11-17; 2012.

    21. Zidichouski, J.A.; Mastaloudis, A.; Poole, S.J.; Reading, J.C.; Smidt, C.R. Clinical validation of a non-invasive, Raman spectroscopic method to assess carotenoid nutritional status in humans. Journal of the American College of Nutrition. 28(6):687-693; 2009. DOI: 10.1111/j.1749-6632.2012.06610.x. PMID: 22758643.

    22. Mastaloudis, A.; Traber, M.G., Carstensen, K.; Widrick, J.J. Antioxidants did not prevent muscle damage in response to an ultramarathon run. Medicine and Science in Sports and Exercise. 38(1):72-80; 2006. DOI: 10.1111/j.1749-6632.2012.06610.x. PMID: 22758643.

    23. Mastaloudis, A.; Morrow, J.D.; Hopkins, D.W.; Devaraj, S.; Traber, M.G. Antioxidant supplementation prevents exercise-induced lipid peroxidation, but not inflammation, in ultramarathon runners. Free Radical Biology & Medicine. 36(10):1329-1341; 2004. DOI: 10.1111/j.1749-6632.2012.06610.x. PMID: 22758643.

    24. Mastaloudis, A.; Yu, D.; O'Donnell, R.P.; Frei, B.; Dashwood, R.; Traber, M.G. Exercise results in DNA damage as detected by the comet assay. Free Radical Biology & Medicine 36(8):966-975; 2004. DOI: 10.1111/j.1749-6632.2012.06610.x. PMID: 22758643.

    25. Mastaloudis, A.; Leonard, S.W.; Leklem, J.; Traber, M.G. Oxidative stress in athletes during extreme endurance exercise. Free Radical Biology & Medicine 31(7):911-922; 2001. DOI: 10.1016/s0891-5849(01)00667-0. PMID: 11585710.

    1. Mastaloudis, A. and Traber, M.G. Vitamin E. In: Sports Nutrition: Vitamins and Trace Elements, edited by J. A. Driskell and I. Wolinsky, Boca Raton: CRC Press, 183-200; 2006.

    2. Traber, M.G. and Mastaloudis, A. Vitamins C and E in the Prevention of Oxidative Stress, Inflammation and Fatigue from Exhaustive Exercise. In: Nutrient Composition of Rations for Short-Term, High-Intensity Combat Operations, edited by Institute of Medicine Committee on Military Nutrition and Research, Washington, D.C.: The National Academies Press, 243-256; 2006.

Contact us

Interested in working together? Fill out some info and we will be in touch shortly. We can’t wait to hear from you!