Ph.D. Nutrition Biochemistry Oregon State University, Corvallis, OR   

Dissertation Title: Inhibition of Exercise-Induced Oxidative Stress, Inflammation and Muscle Damage by Prior Supplementation with the Antioxidant Vitamins E and C

M.S. Exercise Physiology Oregon State University, Corvallis, OR                                             

Dissertation Title: Assessment of Oxidative Stress in Athletes During Extreme Exercise Using Deuterium-Labeled Vitamin E

B.A.  Biological Sciences University of California at Santa Barbara, Santa Barbara, CA                   

1. Mastaloudis, A.; Holcomb, L.; Fahey, J.; Olson, C.; Nieman, D.; Colin, Kay, C.; O'Donnell, R.; Pecorelli, A.; Kinney, M.; Li, Y.; Ishaq, S. and Valacchi, G. Active Exogenous Myrosinase from Mustard Seed Increases Bioavailability of Sulforaphane from a Glucoraphanin-Rich Broccoli Seed Extract in a Human Clinical Study. Communications Medicine-Nature. 2026 (Accepted pending revisions).

2. Zhu, Z.; Cremonini, E.; Mastaloudis, A.; Mitchell, A.E.; Bornhorst, G.M. and Oteiza, P.I. Optimization of sulforaphane bioavailability from a glucoraphanin-rich broccoli seed extract in a model of dynamic gastric digestion and absorption by Caco-2 cell monolayers. Food and Function. 16(1):314–328; 2025. DOI: 10.1039/d4fo04561k

3. Zhu, Z.; Cremonini, E.; Mastaloudis, A. and Oteiza, P.I. Glucoraphanin and sulforaphane mitigate TNFα-induced Caco-2 monolayers permeabilization and inflammation. Redox Biology. 76:103359; 2024. https://doi.org/10.1016/j.redox.2024.103359.

4. Zhu, Z.; Lerno, L.; Cremonini, E.; Oteiza, P.I.; Mastaloudis, A.; Bornhorst, G.M. and Mitchell, A.E. Robust UHPLC-(ESI+)-MS/MS method for simultaneous analysis of glucoraphanin, sulforaphane, and sulforaphane metabolites in biological samples. ACS Food Science & Technology. 3(7):1300-1310; 2023. DOI: 10.1021/acsfoodscitech.3c00173

5. Cremonini, E.; Daveri, E.; Iglesias, D.E.; Kang, J.; Wang, Z.; Gray, R.; Mastaloudis, A.; Kay, C.D.; Hester, S.N.; Wood, S.M.; Fraga, C.G.; Oteiza, P.I. A randomized placebo-controlled cross-over study on the effects of anthocyanins on inflammatory and metabolic responses to a high-fat meal in healthy subjects. Redox Biology. May;51:102273; 2022. DOI: 10.1016/j.redox.2022.102273. Epub 2022 Mar 1. PMID: 35255426

6. De La Rosa, A.; Olaso-Gonzalez, G.; Garcia-Dominguez, E.; Mastaloudis, A.; Hester, S.N.; Wood, S.M.; Gomez-Cabrera, M.C.; Viña, J. Glucosamine Supplementation Improves Physical Performance in Trained Mice. Medicine & Science in Sports & Exercise. Mar 1;54(3):466-474; 2022. DOI: 10.1249/MSS.0000000000002821. PMID: 34711707.

7. Cremonini, E.; Daveri, E.; Mastaloudis, A. and Oteiza, P.I. (–)-Epicatechin and anthocyanins modulate GLP-1 metabolism: evidence from mice and GLUTag L cells. Journal of Nutrition. Jun 1;151(6):1497-1506.; 2021. DOI: 10.1093/jn/nxab029. PMID: 33693759

8. Gambini, J.; Gimeno-Mallench, L.; Olaso-Gonzalez, G.; Mastaloudis, A.; Traber, M.G.; Monleón, D.; Borrás, C. and Viña J. Moderate Red Wine Consumption Increases the Expression of Longevity-Associated Genes in Controlled Human Populations and Extends Lifespan in Drosophila melanogaster. Antioxidants (Basel). Feb 16;10(2):301; 2021. DOI: 10.3390/antiox10020301. PMID: 33669360.

9. Mastaloudis, A.; Subramaniam, P.; Wood, S.M.; Hester, S.N.; McGlade, E.C.; Renshaw, P.F. and Yurgelun-Todd, D.A. Supplementation with a putative calorie restriction mimetic micronutrient blend increases glutathione concentrations and improves neuroenergetics in brain of healthy middle-aged men and women. Free Radical Biology and Medicine. Jun;153:112-121; 2020. DOI: 10.1016/j.freeradbiomed.2020.04.017. PMID: 32335159.

10. Woodby, B.; Schiavone, M.L.; Pambianchi, E.; Mastaloudis, A.; Hester, S.N.; Wood, S.M.; Pecorelli, A. and Valacchi, G. Particulate Matter Decreases Intestinal Barrier-Associated Protein Levels in 3D Human Intestinal Model. International Journal of Environmental Research and Public Health. May;17(9):3234; 2020. DOI: 10.3390/ijerph17093234. PMID: 32384765. 

11. Serna, E.; Mastaloudis, A.; Wood, S.M.; Hester, S.N.; Prolla T.A. and Vina, J. A novel micronutrient blend mimics calorie restriction transcriptomics in multiple tissues of mice and increases life and healthspan in C. elegans. Nutrients. Feb;12(2):486; 2020. DOI: 10.3390/nu12020486. PMID: 32075050.

12. Cremonini, E.; Daveri, E.; Mastaloudis, A.; Adamo, A.M.; Mills, D.; Kalanetra, K.; Hester, S.N.; Wood, S.M.; Fraga, C.G. and Oteiza, P.I. Anthocyanins protect the gastrointestinal tract from high fat diet-induced alterations in redox signaling, barrier integrity and dysbiosis. Redox Biology. Sep;26:101269; 2019. DOI: 10.1016/j.redox.2019.101269. PMID: 31330482.

13. Hester, S.N.; Mastaloudis, A.; Gray, R.; Antony, J.; Evans, M. and Wood, S.M. Efficacy of an anthocyanin and prebiotic blend on intestinal environment in obese male and female subjects. Journal of Nutrition and Metabolism. 7497260; 2018. DOI: 10.1155/2018/7497260. PMID: 30302287

14. Daveri, E.; Cremonini, E.; Mastaloudis, A.; Hester, S.N.; Wood, S.M.; Waterhouse, A.L.; Anderson, M.; Fraga, C.G. and Oteiza, P.I. Cyanidin and delphinidin modulate inflammation and altered redox signaling improving insulin resistance in high fat-fed mice. Redox Biology. 18:16-24; 2018. DOI: 10.1016/j.redox.2018.05.012. PMID: 29890336.

15. Cremonini, E.; Mastaloudis, A.; Hester, S.N.; Verstraeten, S.; Anderson, M.; Wood, S.M.; Waterhouse, A.L.; Fraga, C.G. and Oteiza, P.I. Anthocyanins inhibit tumor necrosis alpha-induced loss of Caco-2 cell barrier integrity. Food and Function. 8(8):2915-2923; 2017. DOI: 10.1039/c7fo00625j. PMID: 28740990.

16. Barger, J.L.; Vann, J.M.; Cray, N.L.; Pugh, T.D.; Mastaloudis, A.; Hester, S.N.; Wood, S.M.; Newton, M.A.; Weindruch, R. and Prolla, T.A. Identification of tissue-specific transcriptional markers of caloric restriction in the mouse and their use to evaluate caloric restriction mimetics. Aging Cell. 16(4):750-760; 2017. DOI: 10.1111/acel.12608. PMID: 28556428.

17. Wood, S.M.; Mastaloudis, A.F.; Hester, S.N.; Gray, R.; Kern, D.; Namkoong, J. and Draelos, Z.D. Protective effects of a novel nutritional and phytonutrient blend on ultraviolet radiation-induced skin damage and inflammatory response through aging defense mechanisms. Journal of Cosmetic Dermatology. 16(4):491-499; 2017. DOI: 10.1111/jocd.12295. PMID: 27885783.

18. Barger, J.L.; Van, J.M.; Mastaloudis, A.; Wood, S.M.; Bartlett, M.R.; Prolla, T.A.; Weindruch, R. Identification of transcriptional targets of healthspan in adipose tissue and modulation by resveratrol. Nutrition and Aging. 2:157-63; 2014.

19. Mastaloudis, A. and Wood, S.M. Age-related changes in cellular protection, purification and inflammation-related gene expression: role of dietary phytochemicals. Annals of the New York Academy of Sciences. 1259(1):112-120; 2012. DOI: 10.1111/j.1749-6632.2012.06610.x. PMID: 22758643

20. Mastaloudis, A. A unique nutritional formulation to promote cellular protection and purification via induction of the Nrf2-mediated ARE/Phase II detoxification pathways. Second International Conference on Environmental Stressors in Biology and Medicine. Medimond s.l.r. Bologna, Italy. 11-17; 2012.

21. Zidichouski, J.A.; Mastaloudis, A.; Poole, S.J.; Reading, J.C.; Smidt, C.R. Clinical validation of a non-invasive, Raman spectroscopic method to assess carotenoid nutritional status in humans. Journal of the American College of Nutrition. 28(6):687-693; 2009. DOI: 10.1111/j.1749-6632.2012.06610.x. PMID: 22758643.

22. Mastaloudis, A.; Traber, M.G., Carstensen, K.; Widrick, J.J. Antioxidants did not prevent muscle damage in response to an ultramarathon run. Medicine and Science in Sports and Exercise. 38(1):72-80; 2006. DOI: 10.1111/j.1749-6632.2012.06610.x. PMID: 22758643.

23. Mastaloudis, A.; Morrow, J.D.; Hopkins, D.W.; Devaraj, S.; Traber, M.G. Antioxidant supplementation prevents exercise-induced lipid peroxidation, but not inflammation, in ultramarathon runners. Free Radical Biology & Medicine. 36(10):1329-1341; 2004. DOI: 10.1111/j.1749-6632.2012.06610.x. PMID: 22758643.

24. Mastaloudis, A.; Yu, D.; O'Donnell, R.P.; Frei, B.; Dashwood, R.; Traber, M.G. Exercise results in DNA damage as detected by the comet assay. Free Radical Biology & Medicine 36(8):966-975; 2004. DOI: 10.1111/j.1749-6632.2012.06610.x. PMID: 22758643.

25. Mastaloudis, A.; Leonard, S.W.; Leklem, J.; Traber, M.G. Oxidative stress in athletes during extreme endurance exercise. Free Radical Biology & Medicine 31(7):911-922; 2001. DOI: 10.1016/s0891-5849(01)00667-0. PMID: 11585710.

1. Mastaloudis, A. and Traber, M.G. Vitamin E. In: Sports Nutrition: Vitamins and Trace Elements, edited by J. A. Driskell and I. Wolinsky, Boca Raton: CRC Press, 183-200; 2006.

2. Traber, M.G. and Mastaloudis, A. Vitamins C and E in the Prevention of Oxidative Stress, Inflammation and Fatigue from Exhaustive Exercise. In: Nutrient Composition of Rations for Short-Term, High-Intensity Combat Operations, edited by Institute of Medicine Committee on Military Nutrition and Research, Washington, D.C.: The National Academies Press, 243-256; 2006.